Description: This volume of the IARC Monographs provides evaluations of the carcinogenicity of: N, N-dimethylformamide, a solvent produced in high volumes and commonly used in many industrial processes; 2-mercaptobenzothiazole, a rubber accelerant and preservative; the rocket fuel hydrazine; the widely used fire retardant tetrabromobisphenol A; 1-bromopropane, a solvent used in dry cleaning, degreasing and adhesive resins; the seed fumigant 3-chloro-2-methylpropene; and N, N-dimethyl-p-toluidine, a hardening agent in dental and bone adhesives.
Exposure to all seven agents considered may occur in the general population as well as in different occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents.Brief description: The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.