Description:
Written by a top biostatistics researcher, this is the first book entirely devoted to the statistical design and analysis of biosimilarity and interchangeability of biosimilar products. It includes comparability tests of important quality attributes at critical stages of the manufacturing processes of biologic products. The book focuses on the scientific factors and practical issues related to the design and analysis of biosimilar studies. It covers most of the statistical questions encountered in various study designs at different stages of research and development of biological products.
Review Quotes:
"This book extensively covers both statistical and regulatory considerations from design to analysis of biosimilarity. ... it is well presented and comprehensively covers fundamental issues and some of the newly developed methods for biosimilarity studies. The book is very balanced between scientific aspects and regulatory requirements. In addition, the reference lists give readers helpful information. ... a valuable resource for anyone interested and involved in biosimilarity studies."
--Biometrics, September 2014
"[Professor] Chow's book Biosimilars: Design and Analysis of Follow-On Biologics ... is the first book ever written on this topic. I commend Professor Chow for his effort to introduce the topic ... Overall, this is a worthwhile reference book for statisticians interested in understanding biosimilar product development and evaluation."
--Yi Tsong, PhD, Center for Drug Evaluation and Research, US Food and Drug Administration, USA, in Journal of Biopharmaceutical Statistics