Description: Enzymes: Biomarkers, Targets and Therapy examines the critical role of enzymes in drug discovery, diagnostics, and therapeutic applications, providing essential insights for clinicians, biomedical researchers, and pharmaceutical industry professionals. This book highlights the utility of enzymes as biomarkers for disease diagnosis, targets for innovative drug discovery, and therapeutic agents in treating various conditions. Within its comprehensive chapters, the book discusses enzymatic biomarkers in neurodegenerative disorders such as Alzheimer's disease and α-synucleinopathies, where enzymes are pivotal in understanding disease mechanisms and potential interventions.
It covers enzymatic drug targets in cancers and diabetes, offering insights into harnessing enzymes for novel therapeutic strategies. Additionally, the book explores the role of enzymes in lipid and hypertensive disorders, emphasizing their potential in managing these conditions. Further, the book examines enzymes as therapeutic agents in autoimmune and infectious diseases, featuring approaches like CRISPR-Cas9 gene editing to tackle antimicrobial resistance. By providing curated information, this book equips its audience with the necessary knowledge to explore new directions in drug discovery and enzymatic therapy.Brief description: Dr. Priyanka Bajaj, PhD, Editor is an Assistant Professor at the Department of Chemical Sciences at the National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India. Her group is working on the cutting-edge field of Biopharmaceutical Proteins and Enzymes. The group explores industrially important biopharmaceutical proteins like antibodies, antibody-drug conjugates (ADCs), and enzymes, including P450s, Ketoreductases, Transaminases, and others. She has 15 years of experience from her two post-doctorates at the University of Rochester, New York, and the University of Michigan, Ann Arbor, MI, USA, as well as in her PhD from NIPER, Mohali. She is the author and co-author of multiple reputed international research articles in reputed journals like Angewandte Chemie, Journal of Organic Chemistry, Biochemie and others and patents and has been awarded several national and international academic awards. She has supervised 15 master students by now and is currently supervising 08 masters and 06 PhD students.