Description: Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.
The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.Brief description: Gary Tse is a medical scientist focusing on personalized care, health informatics and big data analytics. He is a professor in Hong Kong Metropolitan University and holds a joint position as reader at the University of Kent and public health consultant at the Medway Council in local government, UK. He serves as a professor at the Department of Cardiology and principal investigator at the Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, China. He is a visiting professor at the Faculty of Health and Medical Sciences, University of Surrey, and an honorary associate professor at the School of Pharmacy, University College London. He is an author of more than 500 scientific papers and an expert reviewer for >50 international journals in cardiology, cardiac electrophysiology, cardiovascular biology and epidemiology and five grant bodies from New Zealand, Poland, Sweden and the UK.