Description: Brain Energy Metabolism in Alzheimer's Disease - Part A, published as Volume 186 of the serial International Review of Neurobiology, provides a comprehensive and up-to-date synthesis of molecular, cellular, and systemic mechanisms underpinning energy dysregulation in neurodegeneration, with a primary focus on Alzheimer's disease. This volume assembles expert-led reviews exploring key metabolic pathways--from glutamate-glutamine cycling and mitochondrial bioenergetics to neurovascular coupling, circadian regulation, and gut-brain axis interactions--while also examining emerging contributors such as environmental toxins, PFAS exposure, and microplastic-induced neurotoxicity. Together, these chapters illuminate how disrupted energy homeostasis intersects with oxidative stress, inflammation, and neuronal senescence, offering new insights into disease pathophysiology and therapeutic targeting.
Brief description:
Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer's Disease.