Description: Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.
Brief description: Dr. Patricio Riva-Posse, MD is an Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine. After completing his training in Neurology and in Psychiatry, he has focused his clinical and research work in the field of treatment resistant mood disorders. He is the Director of the Treatment Resistant Depression Clinic, and Director of Neuromodulation Services. He conducts research in invasive and non-invasive neuromodulation as well as novel pharmacological approaches. He is an investigator in NIH-funded project studying subcallosal cingulate deep brain stimulation. Born in Argentina, he earned his Medical Doctor degree from the Universidad de Buenos Aires.
Review Quotes: *4 stars* "...presents a comprehensive, extensive review of the current understanding of depression, its epidemiology, presentation, predictors, socioeconomic burden, neurobiology, and effectiveness of pharmacotherapy and nonpharmacological and psychotherapeutic interventions. This book extensively reviews the current understanding of treatment-resistant depression (TRD), covering a wide variety of topics including disease burden, presentation, and course.... [A]ppropriate for a broad audience, ... covers a broad range of topics across 500-plus pages and 40 chapters, ... a resource that should be on the shelves of those managing this complicated and challenging population." --(c)Doody's Review Service, 2023, Michael Easton, MD (Rush University Medical Center)