Description:
Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomesin the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medicaldisciplines, as well as their role in cell-cell communication. It is intended to serve as a referencesource for clinicians, physicians, and research scientists who wish to gain insight into the mostrecent advances in this rapidly growing field.
The exosome revolution may well be the greatest advance in physiology and medicine sinceantibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is amajor breakthrough in our understanding of how cells function.
Brief description: John Raymond Smythies, M.B. B.Chir., M.D., F.R.C.P., F.R.C. Psych. (1922-2019) was the Director of the Integrative Neuroscience Program in the Department of Psychology at the University of California San Diego. As a pre-eminent neuropsychiatrist and neuroscientist he made significant contributions to both these disciplines. Together with Humphry Osmond he developed the first biochemical theory of schizophrenia - the transmethylation hypothesis. This has recently come back into focus following the finding that DNA methylation is abnormal in schizophrenia. He made extensive contributions to knowledge in a number of fields including the neuropharmacology of psychedelic drugs; the functional neuroanatomy of synapses with particular regard to the role of synaptic plasticity, endocytosis and redox factors; the role in the brain of orthoquinone metabolites of catecholamines; and, in particular, theories of brain-consciousness relations. More recently he developed foundational hypotheses and theories specific to the function of exosomes, telocytes and the claustrum, and on epigenetic processes in information processing in the brain. Professor Smythies served as President of the International Society of Psychoneuroendocrinology from 1970-1974, Consultant to the World Health Organization from 1963-1968, and Editor of the International Review of Neurobiology from 1958-1991. He was elected a member of the Athenaeum in 1968. He held the positions of Professor Emeritus and the Charles Byron Ireland Professor of Psychiatric Research at the University of Alabama Medical Center at Birmingham, Visiting Scholar at the Center for Brain and Cognition, University of California San Diego, and Senior Research Fellow at the Institute of Neurology, University College London. He published over 240 scientific papers and sixteen books. https: //en.wikipedia.org/wiki/John_Raymond_Smythies