Description:
Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail.
This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.
Brief description: Dr. Alexey Moskalev earned his PhD from Moscow State University, Moscow, Russia in 2001. Since that time, Dr. Moskalev's research has focused on the genetics of longevity and aging, with emphasis on epigenetic regulation of aging, longevity, and stress resistance in animal models. He was a key contributor towards creating a database of biomarkers of aging in the Digital Ageing Atlas (DAA), and his lab has been supported by grants from the Russian Basic Research Foundation, the Presidium of the Russian Academy of Sciences, and the President of the Russian Federation through a program that funds leading young scientists. Currently, Dr. Moskalev is Vice-President of the Syktyvkar Branch of Russian Gerontology Society; President of the Komi branch of the Vavilov Society of Geneticists and Breeders; and a member of the editorial boards of Aging, Biogerontology, Frontiers in Genetics of Aging, Aging and Disease, Genes & Cells, and the SM Journal of Food and Nutritional Disorders. Additionally, he is Co-chair of the International Symposiums "Genetics of Aging and Longevity" and "Biomedical Innovation For Healthy Longevity". Dr. Moskalev has published more than eighty scientific papers in peer reviewed journals on topics related to the genetics of aging and longevity, as well as DNR repair and defense genes in animal models.